Cervical spinal degenerative disease in multiple sclerosis

Background and purpose Root cord irritation from cervical spinal degenerative disease (SDD) may share clinical features with progressive multiple sclerosis (MS), so diagnostic overshadowing occur. We hypothesized that stenotic SDD is commoner in people MS, compared to controls. Methods A retrospective case–control study of 111 cases (56 MS 55 age- sex-matched controls) was conducted. Five types (disc degeneration, posterior disc protrusion, endplate changes, canal stenosis foraminal stenosis) were assessed objectively on magnetic resonance imaging using published scales. Multivariable regression analysis performed. Results Moderate-to-severe degeneration occurred more frequently In multivariable regression, three times likely (odds ratio 3.20, 95% confidence interval 1.27, 8.09; p = 0.014), severe (p 0.009). This finding confirmed evaluation radiology reports the same population. Foraminal twice as relapsing-remitting MS. Conclusions People are susceptible stenosis. higher index suspicion for required when appropriate neurological symptoms occur setting guide treatment or monitoring.